Donation Rationale

Today, kidney issues dramatically impact global health, especially the health of children. In developing countries, millions of people – most of them children – die each year from diseases that are preventable and treatable. For many of these children, kidney problems represent a serious threat to their survival.

HIV Associated Nephropathy (HIVAN)

  • Approximately 2.5 million children under age 15 have AIDS
  • Kidney disease in HIV is associated with increased mortality
  • At least 2 – 10 % of HIV patients, and likely many more, are also affected by HIVAN (confirmed by biopsy)

Diarrheal Disease

  • Diarrhea is the #2 cause of death in children worldwide
  • Diarrheal disease can result in severe fluid and electrolyte disturbances and acute kidney injury

Low Birth Weight

  • Infants with low birth weight are seen in malnourished populations, disproportionately in low income areas
  • Low birth weight infants are at greater risk of small kidneys
  • These small babies are more likely to develop significant elevations in blood pressure as teenagers

Urological Disease

  • Congenital abnormalities of the bladder and kidneys are a major cause of chronic kidney disease in children, and are often not recognized in infancy
  • After birth, these children are at risk for obstruction and infection, which worsens their prognosis
  • There are many non-invasive tests such as renal ultrasound and urine dipsticks, which can be used to detect kidney and bladder abnormalities in utero and shortly after birth
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