Experience with Iodine Induced Hypothyroidism in Pediatric Patients on Peritoneal Dialysis: An International Survey

Dear IPNA Colleagues,

Please consider participating in our research study by completing a one-time survey regarding iodine induced hypothyroidism in pediatric peritoneal dialysis patients, described below.

Children who receive peritoneal dialysis (PD) are at increased risk for thyroid dysfunction. Contributing factors include a decreased response to thyrotropin-releasing hormone, reduced affinity of thyroid hormones to thyroid-binding proteins, inflammation, malnutrition, mineral deficiencies, and metabolic acidosis. Patients receiving PD can also lose thyroid-binding proteins in the dialysis effluent. A poorly appreciated cause of hypothyroidism in the PD population is iodine overload, particularly in infants and small children. Although there are multiple causes of iodine exposure, one of the most common yet often forgotten sources is povidone-iodine–impregnated gauze in the sterile transfer set cap associated with PD. We recently reported iodine induced hypothyroidism in 4 patients (Mannemuddhu 2020). The purpose of this survey is to increase awareness of this complication among pediatric nephrologists and to improve monitoring and prevention of iodine induced hypothyroidism in this population.

To help target our efforts, we would like to gather information regarding the current awareness of this issue among our peers. This brief (3-5 minute) survey was created to better understand current practices and knowledge regarding iodine induced hypothyroidism in pediatric PD patients. The results of this anonymous data will be shared throughout the International Pediatric Nephrology Association (IPNA) community.

Participation is, of course, voluntary.  Your confidentiality will be protected to the greatest extent possible and you do not have to give any information you do not wish to give.   No honorarium/compensation is associated with this survey. This project was deemed IRB exempt from the participating institutions. Please contact Dr. Sudha Mannemuddhu at ss[email protected] if you have any questions about this study.

You may open the survey in your web browser by clicking the link below:
Experience with Iodine Induced Hypothyroidism in Pediatric Patients on Peritoneal Dialysis: An International Survey

Thank you for your time and participation.  We greatly appreciate it.


Sai Sudha Mannemuddhu, MD

Pediatric Nephrology

East Tennessee Children’s Hospital

Heather A. Morgans, DO

Pediatric Nephrology Fellow

Children’s Mercy Hospital
Kansas City, MO

Bradley A. Warady, MD

The McLaughlin Family Endowed Chair in Nephrology

Professor of Pediatrics

University of Missouri-Kansas City School of Medicine

Director, Division of Nephrology

Director, Dialysis and Transplantation

Children’s Mercy Kansas City

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